Tuesday, July 23, 2013

News in Brief: Mouse retinas grown in lab

Transplanted cells can function in rodents' eyes

By Tina Hesman Saey

Web edition: July 22, 2013

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Eye candy

Researchers grew primitive retinas (one shown, with proteins that collect and transmit light signals in green and red) by embedding mouse embryonic stem cells in a gel. Immature cells from the lab-grown structures can integrate into adult eyes.

Credit: Anai Gonzalez-Cordero

Retina cells can be grown from mouse stem cells in the laboratory and become working parts of a mouse?s eye, a new study indicates.

Last year, Robin Ali of University College London and colleagues demonstrated that immature retina cells from newborn mice could form rod cells ? a type of light-gathering cell ? that wire into the retinas of night-blind adult mice (SN: 5/19/12, p. 13). For the technology to help restore sight in people, such as those with macular degeneration, the researchers needed to come up with a ready source of immature retinal cells.

Ali and colleagues report July 21 in Nature Biotechnology that they have devised a way to coax mouse embryonic stem cells to form primitive retinas in a laboratory dish. Most researchers who have tried to grow retinas have failed. The trick, Ali?s team found, was to embed the stem cells in a gel instead of growing the cells on top of the dish. The gel provided cues to mimic normal developmental signals.

The stem cells formed primitive retinas from which the researchers harvested cells to inject into the eyes of adult mice. A small number of those lab-grown cells matured into rods that formed connections with the mice?s optical nerves.

Source: http://www.sciencenews.org/view/generic/id/351781/title/News_in_Brief_Mouse_retinas_grown_in_lab

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Monday, July 22, 2013

Stinky corpse flower blooms in Washington

A towering plant that smells like rotting meat and is native to the Indonesian rainforest is in full bloom in the US capital, drawing throngs of tourists, officials said Monday.

The titan arum, among the world's largest plants, began blooming on Sunday at the United States Botanic Garden, and its petals are expected to stay open for just 24 to 48 hours.

"Then it will collapse quickly," said the Botanic Garden, which is broadcasting the flower and the camera-raising crowds it is drawing live on the Internet.

The flower is eight feet tall (2.4 meters) and smells of decomposing flesh in order to attract pollinators like dung beetles.

Its blooming is unpredictable, and may happen every few years or every few decades.

"The plant requires very special conditions, including warm day and night temperatures and high humidity, making Botanic Gardens well suited to support this strange plant outside of its natural range," the garden said.

The plant was first discovered in 1878 and the last time one bloomed at the US Botanic Garden was in 2007.

"We have had more than 98,000 people come visit from July 11 through July 21... unbelievable number of people!" said garden spokeswoman Laura Condeluci.

Visitors waited in line in soaring summer heat for a chance to see and smell the flower, but some were disappointed that the worst of the stench had already passed.

"Not nearly as smelly as I had hoped," tweeted one visitor named Robin.

Explore further: Plant that only flowers once in seven years has blossomed

Source: http://phys.org/news293724340.html

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NBA Trade Rumors: Franchise Cornerstones That Shouldn't Be Moved

The faces of some smaller NBA markets and one rebuilding big market are supposedly being tossed around to other franchises. Even if some reports turn out to be true, don't expect any landscape-changing moves from Boston, Milwaukee or Portland.

Each of these three teams has had its star player ask for or involved in trade possibilities according to several media outlets. While these rumors could have truth to them, it makes no sense for any of the three franchises to deal their cornerstones.

Here is why LaMarcus Aldridge, Brandon Jennings and Rajon Rondo aren't going anywhere this offseason.

?

LaMarcus Aldridge

Chris Haynes of Comcast Sportsnet NorthWest is reporting that Aldridge arranged a meeting with Portland general manager Neil Olshey in a Las Vegas hotel lobby on July 14.

Highlights from Aldridge's first NBA all-star season in 2011-12.

Haynes' source told him that the two-time NBA All-Star wanted to meet with Olshey to discuss trade scenarios for him to leave the Trail Blazers.

While Aldridge might have made it clear he would like to move out of Portland, he shouldn't get his wish at least this offseason.

The Trail Blazers ended the 2012-13 regular season on a 13-game losing streak. If the team hadn't done so, it would have been in contention for the No. 8 playoff seed in the Western Conference.

Teammates Nicolas Batum and Damian Lillard averaged 14.3 and 19 points per game just last season. Paired with Aldridge's 21.1 points per game average last year, the Trail Blazers usually had three starters posting double-digit points on any given night.

Unless the Trail Blazers can convince a team like Minnesota or Atlanta to give up its star player for Aldridge, there's no reason to do the deal. Even if Kevin Love or Al Horford were attainable in exchange for Aldridge, neither team involved would benefit from the swap.

?

Brandon Jennings

One NBA star who has not been quiet about wanting to change scenery is Jennings. The Bucks star wants out of Milwaukee for a bigger market and contract.

The Bucks have been in search of a deal that would give Jennings his wish in exchange for a point guard, but to no avail so far. Even with both sides working toward an exit for the former No. 10 overall draft pick, another year together would be the better option.

Which player is most likely to stay with their current team?

    Which player is most likely to stay with their current team?

  • LaMarcus Aldridge

  • Brandon Jennings

  • Rajon Rondo

The Bucks were a playoff team just last year and could easily be one again this season. With Boston rebuilding, the other Eastern Conference teams has one less powerhouse to worry about.

Jennings can get out of Milwaukee after next season when his $4.5 million, one-year deal expires if he still wants to.

Playing one year with the Bucks would give the team another postseason chance and Jennings another opportunity to showcase his talents for his next team.

If Jennings is able to help his team get to the playoffs again in the 2013-14 season, he'll have every team who needs a point guard pursuing him in free agency.

The down side to this scenario for Milwaukee is that the team would get no compensation for Jennings' departure.

While that may be true, two straight trips to the playoffs would make the Bucks sound like a team other free agents might want to sign with the following year.

?

Rajon Rondo

Rondo is no stranger to being rumored in potential trades, and the latest to surface linked him to the Detroit Pistons.?

Pistons president of basketball operations Joe Dumars denied offering the Boston Celtics Brandon Knight in exchange for Rondo. Gary Washburn of The Boston Globe (via subscription) recently reported that the Pistons are "quite interested" in Rondo but don't have a package that interests Celtics president of basketball operations Danny Ainge.

When asked by Vince Ellis of The Detroit Free Press about how the point guard would fit in Detroit, Dumars simply said: "At this point, I really can?t start talking about somebody else?s player. That rumor isn't even true."

If the rumor is true and even if Dumars is the one who initiated the conversation, Ainge should not be looking to trade Rondo.

Boston has already shipped off Kevin Garnett and Paul Pierce this offseason. While the two former Celtics were shipped off due to their increasing age, Rondo should be the young superstar point guard the team rebuilds around, not without.

The Kentucky product has averaged at least 10 points and 11 assists per game each of the past three seasons. The last time Rondo averaged less than 10 points per game in a single season was his rookie year in 2006-07.

Don't forget that it was new Celtics coach Brad Stevens who told Baxter Holmes (via subscription) of the Globe, that there is no bigger Rondo fan than Stevens himself.

The Celtics have a long way to go to get back into the NBA championship hunt, but it would be an even longer road without Rondo at point guard.

Source: http://bleacherreport.com/articles/1711108-nba-trade-rumors-franchise-cornerstones-that-shouldnt-be-moved

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Sunday, July 21, 2013

Froome locks up Tour de France

ANNECY-SEMNOZ, France (AP) ? Chris Froome retained his big race lead Saturday to all but ensure he will become Britain's second consecutive Tour de France champion.

Only an accident or other freak mishap on Sunday's largely ceremonial final ride to Paris could stop Froome from winning the 100th Tour, a year after Bradley Wiggins won the 99th.

Froome finished third in a dramatic Stage 20 to the ski station of Annecy-Semnoz in the Alps that decided the other podium placings.

Nairo Quintana from Colombia won the stage and moved up to second overall.

Joaquim Rodriguez from Spain rode in 17 seconds behind Quintana. He moved up to third overall. Froome's lead is more than five minutes on both.

Alberto Contador, who had been second at the start of the day, struggled on the final climb and dropped off the podium.

The 125-kilometer (78-mile) trek was the last of four successive stages in the Alps and the final significant obstacle Froome needed to overcome before Sunday's usually relaxed ride to the finish on the Champs-Elysees in Paris. That 133-kilometer (82-mile) jaunt starts in Versailles.

Froome's dominance at this Tour was such that this victory could very well be the first of several. At 28, he is entering peak years for a bike racer. He proved at this Tour that he excels both in climbs and time trials ? skills essential for those who want to win cycling's premier race. He also handled with poise and aplomb questions about doping in cycling and suspicions about the strength of his own performances. He insisted he raced clean.

Froome first took the race lead and the yellow jersey that goes with it on Stage 8, when he won the climb to the Ax-3 Domaines ski station in the Pyrenees. On Sunday's Stage 21, he will wear the yellow jersey for the 13th straight day.

Froome told French television that when he passed the sign showing 2 kilometers (about 1 mile) to go on Saturday's final climb, "for the first time I realized that it was almost won."

"It was hard today," he said. "Rodriguez and Quintana raced very strongly."

Sunday "will be a day for sprinters on the Champs-Elysees. For us, it is done."

Saturday's stage did a big loop south of Annecy, through the mountains of Savoie between the lakes of Annecy and Bourget. This is cheese-making country, with lush Alpine pastures and dense, naturally cool forests.

Quintana's win also secured him the spotted jersey awarded to riders who pick up the most points on mountain climbs. He also retained the white jersey as the Tour's best young rider. He wiped away tears in his news conference as stage winner.

"I couldn't ask for more," he said. "I got nearly everything. It was fabulous."

"It's a very special day in Colombia. A big party and the whole of Colombia is celebrating."

Unlike on Friday, when storms drenched the pack, the sun shone and the skies were blue on Sataurday. When a motorbike-borne television camera focused on Spanish rider Alejandro Valverde, he motioned that riding in such conditions was hot, tiring work.

The ride took the racers up six climbs. The last two of those were particularly tough. The last steep climb to Annecy-Semnoz, past ski lifts and ski slopes, was rated HC or "Hors Categorie", meaning it's considered too hard to classify.

It was the last really tough climb of this Tour. The riders have just two small humps to climb on their leisurely Sunday ride from the Versailles Palace to the Champs-Elysees' cobbles, where sprinters including Mark Cavendish will battle for the stage win.

Uniquely for the 100th Tour, Stage 21 will set off in the late afternoon, so the race finishes more or less as the sun is setting behind the Arc de Triomphe.

For a chunk of Saturday, the race was led by its oldest rider, Jens Voigt. The 41-year-old German was part of a group of 10 riders that broke away from the pack early in the stage.

"Since I'm almost sure that this was my last Tour, I wanted to say a proper goodbye," said Voigt.

"I gave everything," he said. "I'm happy and now it is over for me."

He was caught in the battle on the final climb. Quintana, Froome and Rodriguez rode off, leaving Contador to labor behind. The winner of 2007 and '09 who was stripped of his 2010 victory and banned for a failed doping test ran out of legs.

Contador placed seventh in the stage, coming in more than two minutes behind Quintana. That dropped him to fourth overall, more than seven minutes back from Froome.

Source: http://news.yahoo.com/froome-locks-tour-france-164046024.html

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State jobs programs gave grants, loans to firms with financial problems

Madison ? To see the recent struggles of the state's jobs programs, take the case of a missing crane, a seemingly untraceable business owner and $83,000 in squandered taxpayer money.

When the state lent the money to Milwaukee Iron Works in the fall of 2010, seemingly everything soured ? from the state's spotty follow-up on the delinquent loan and the firm's eventual status as a tax scofflaw to a shortchanged pension fund for the company's workers and even a sloppy job of lawmaking by legislators eliminating the state program. Taxpayers were left with bad debt and no collateral: The crane that was supposed to back up their loan can't be found.

The case turned up in an ongoing Journal Sentinel review of the state's job programs that encompassed hundreds of records on delinquent loans and matched a database of tax-delinquent companies against firms that have received state jobs incentives such as grants, loans or other awards.

The review found seven companies that benefited from nearly $1.3 million worth of taxpayer subsidies ? including loans, grants and loan guarantees ? and that owe nearly $300,000 in state taxes and other charges, according to a recent count in state records. One business actually owed taxes at the time the state gave it the award, and others, like Milwaukee Iron Works, had growing financial problems that could have been spotted by state officials had they looked deeper into the companies.

"We have to repair the public's trust. This kind of information from the past doesn't help, but it's there," said Paul Radspinner, a board member of the Wisconsin Economic Development Corp. who has been critical of the quasi-public authority in the past but now sees the potential for change.

The Journal Sentinel review confirmed the well-publicized problems at WEDC, the agency that replaced the Department of Commerce under GOP Gov. Scott Walker. But it also found problems under the Department of Commerce under Democratic Gov. Jim Doyle as well as in other state and local agencies.

Last year, the newspaper reported that WEDC had discovered it had failed to track in one centralized database more than $12 million in past-due loans. As a result of those and other problems, the authority's chief financial officer at the time resigned and WEDC undertook a range of reforms of its lending and other financial controls.

Radspinner, president and chief executive officer of Madison biotech firm FluGen Inc., said he's encouraged by a proposed committee on the WEDC board that would use businesspeople like him to evaluate loans before they're awarded.

"I can assure you we're going to be very diligent," Radspinner said.

WEDC chief executive officer Reed Hall said last week that his agency was tracking its entire $58 million loan portfolio. That portfolio had an arrears rate on its loans of about 6% ? several times as high as that of a well-run commercial bank ? but Hall said that's acceptable, given the riskier companies supported by his agency.

"The customers that come to us are usually young companies that cannot get a bank loan because they don't have a credit history," Hall said.

One of those loans was awarded in August 2010 by the Department of Commerce to the metal fabrication firm Milwaukee Iron Works. The award from the department's Forward Innovation Fund aimed to create 10 jobs at the 14-person firm and give the company better profit margins and more capacity by helping it purchase heavy equipment such as an overhead crane.

Milwaukee Iron Works and its owner, Abimael "Aby" Gutierrez, had already had one outstanding unemployment insurance tax warrant filed against them ? a 2005 action in which the state sought a modest $278. For years, Gutierrez had also fallen behind for periods in paying a health and pension fund for his union workers, members of Iron Workers Local 8. Gutierrez also had a minor criminal record, including a 1996 conviction for marijuana possession.

In 2009 and 2010, Milwaukee Iron Works fell behind on its required payments to a union benefits fund. Even after significant collections work, the amount owed still stands at $145,600, according to actions filed by the fund in state and federal court last year. This red flag could have been quickly spotted by state officials deciding on the loan if they had checked on the company with its union or with the association of contractors, said Chris Ahrens, an attorney representing the pension fund.

"They could have done their homework and found this," Ahrens said of state officials.

WEDC spokesman Tom Thieding said the agency checks for unpaid taxes as part of its underwriting and also asks prospective businesses if any of their owners, subsidiaries or officers have outstanding tax liens.

There was a safeguard in the loan contract ? taxpayers got to secure an interest in the crane and other equipment purchased. Gutierrez sent invoices to the state for the purchases in September 2010 and was given $82,870, according to state records and emails from the Department of Justice, charged with recouping the lost money.

For almost the next year, no one in state government had any contact with the company and when the loan came due in October 2011, the company didn't pay, the records show. By then, other financial challenges for the company were apparent, such as the first of numerous money claims filed against Milwaukee Iron Works and one of Gutierrez's other companies, Wisconsin Iron and Steel. In state taxes and fees alone, the two companies are listed as owing more than $112,000.

The Journal Sentinel has requested but not yet received the company's file to see if Milwaukee Iron Works filed its required regular reports with the state.

By August 2011, the Department of Justice had begun working with the Wisconsin Economic Development Corp. to collect on the loan. But there was a problem with the collateral ? the crane was missing.

"I want to add a claim alleging fraud/misrepresentation relating to the purchase of the crane," Department of Justice attorney Debra Remington wrote to WEDC attorney Steven Michels in an August 2011 email. "I can't believe Milwaukee Ironworks took the full draw, when they did not purchase the crane!"

DOJ attorneys were never able to find the crane or confirm whether it was ever purchased, executive assistant Steven Means said. Despite that, Means said, the DOJ didn't pursue a fraud investigation.

In another email, Michels told Remington that generally the former Department of Commerce would have only released the loan money to Milwaukee Iron Works if the crane and other equipment had been purchased, but "there may be limited circumstances where that (practice) would be broken." Michels told Remington that WEDC had kept this policy of generally waiting to disburse money.

Tracking problems

Rep. Peter Barca (D-Kenosha), a member of the WEDC board, said he had been frustrated by the repeated failures within the state's economic development programs.

"They don't have the tracking policies and, when they do have them, they don't seem to follow them," Barca said.

Means said DOJ hadn't been able to track down Gutierrez and believed he had left the area or even the country. Ahrens agreed.

"He just stopped talking to me," Ahrens said. "He disappeared."

But as it turns out, Gutierrez pleaded guilty to a second drunken driving offense July 2 and was sentenced to 21/2 months in the Racine County Jail, where he currently sits. His attorney in that case, Michael M. Hayes, passed along a request for comment, which received no response.

State officials also had to decide what to do with the Milwaukee Iron Works loan if they ever collected on it. Under the Department of Commerce, the Forward Innovation Fund was a revolving loan fund, which meant that the interest and principal payments from its loans went back into the fund to make new loans.

When Walker and GOP lawmakers ended the Department of Commerce in July 2011, they abolished the Forward loan fund and transferred the outstanding loans to WEDC. But they didn't specify where the proceeds from those loans were to go, according to the DOJ emails.

Other agencies

WEDC and the former Department of Commerce weren't the only agencies that turned up in the Journal Sentinel review.

The Wisconsin Housing and Economic Development Authority made a loan guarantee of $100,000 to Junction City Motors LLC in July 2008, according to state records. The business had an outstanding tax claim from the state at the time and now owes more than $9,000 in unpaid taxes and other charges, according to the Department of Revenue. The loan was repaid.

It's worth noting tax delinquencies can arise out of an honest disagreement between a taxpayer and the state or financial challenges. None of the businesses highlighted in this story commented about their cases.

WHEDA spokesman Kevin Fischer said the agency normally asks a borrower to disclose whether he or she is delinquent on any taxes.

"We will pull the file from storage to verify that we did not overlook a negative response, but our electronic database and directory does not make mention by the lender, the borrower, or WHEDA staff, of any tax delinquency prior to approval," Fischer said in a statement.

The furniture distributor Especially for You Ltd. of Coloma received a $306,000 loan of in federal money that flowed through the Department of Commerce and Waushara County in Dec. 7, 2009. Within just months, money claims were being filed against the company by multiple creditors, including the State of Wisconsin, which recently reported being owed more than $110,000 in taxes.

The company's name was removed from the online state delinquent taxpayer list on Friday ? a step that can be taken for undisclosed reasons such as a repayment plan being negotiated or a bankruptcy being filed.

Some of the loans were calculated risks. For instance, $506,000 in federal block grant money was lent to Synergy Web Graphics to reopen a commercial printing facility that had closed in the Dane County community of Mazomanie. The new company reopened the plant in 2007, employing more than 100 people, but it closed the following year.

The company now owes just under $7,000 in unpaid taxes, according to the state.

Hall, WEDC's chief executive, said Wednesday that his agency has hired a new chief financial officer and additional compliance and internal auditing resources as well as a former bank executive to bring "banking discipline" and underwriting to WEDC. New financial tracking software is being purchased and WEDC's board is adding a new committee with two retired bankers and WEDC staff who vet proposed loans.

"We're trying to have more external oversight of our organization," Hall said.

Twitter: twitter.com/jasonmdstein

Source: http://www.jsonline.com/watchdog/watchdogreports/state-jobs-programs-gave-grants-loans-to-firms-with-financial-problems-b9953065z1-216306091.html

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Two-seater sports cars gaining prominence among rich Indians

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Source: www.cartrade.com --- Friday, July 19, 2013
It seems as if the rich and wealthy in India are getting a little extravagant and flashy with their choice of vehicles. Moving on from chauffeurs driven luxury saloons, wealthy Indians are now buying fast and sleek two-door Sports cars. This shift ...read more ...

Source: http://www.cartrade.com/car-bike-news/two-seater-sports-cars-gaining-prominence-among-rich-indians-121186.html

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